High HDL-Cholesterol Paradox: SCARB1-LAG3-HDL Axis.

ABSTRACT:

Purpose of the review

To evaluate recent studies related to the paradox of high HDL-C with mortality and atherosclerotic cardiovascular disease (ASCVD) risk.

Recent findings

Two observational studies (Cardiovascular Health in Ambulatory Care Research Team [CANHEART] and Copenhagen City Heart Study and the Copenhagen General Population Study [Copenhagen Heart Studies]) of adults without pre-existing ASCVD have shown a significant U-shaped association of HDL-C with all-cause and cause-specific mortality. Both studies showed that low HDL-C levels consistently increased hazard risk (HR) for all-cause and cause-specific mortality. In the CANHEART study, high HDL-C levels, HDL-C > 90 mg/dL, were associated with increased HR for non-CVD/non-cancer mortality. In the Copenhagen Heart

SUBMITTER: Rodriguez A 

PROVIDER: S-EPMC7782461 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature