Mutant TP53 interacts with BCAR1 to contribute to cancer cell invasion.

ABSTRACT:

Background

Mutant TP53 interacts with other proteins to produce gain-of-function properties that contribute to cancer metastasis. However, the underlying mechanisms are still not fully understood.

Methods

Using immunoprecipitation and proximity ligation assays, we evaluated breast cancer anti-estrogen resistance 1 (BCAR1) as a novel binding partner of TP53^R273H, a TP53 mutant frequently found in human cancers. The biological functions of their binding were examined by the transwell invasion assay. Clinical outcome of patients was analysed based on TP53 status and BCAR1 expression using public database.

Results

We discovered a novel interaction between TP53^R273H and BCAR1. We found that BCAR1 translocates from the cytoplasm into the nucleus and bi

SUBMITTER: Guo AK 

PROVIDER: S-EPMC7782524 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature