Ontology highlight
ABSTRACT:
SUBMITTER: Lei H
PROVIDER: S-EPMC7782553 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nature communications 20210104 1
Identifying novel drug targets to overcome resistance to tyrosine kinase inhibitors (TKIs) and eradicating leukemia stem/progenitor cells are required for the treatment of chronic myelogenous leukemia (CML). Here, we show that ubiquitin-specific peptidase 47 (USP47) is a potential target to overcome TKI resistance. Functional analysis shows that USP47 knockdown represses proliferation of CML cells sensitive or resistant to imatinib in vitro and in vivo. The knockout of Usp47 significantly inhibi ...[more]