Kinetic analysis of dominant intraprostatic lesion of prostate cancer using quantitative dynamic [¹⁸F]DCFPyL-PET: comparison to [¹⁸F]fluorocholine-PET.

ABSTRACT:

Purpose

Identification of the dominant intraprostatic lesion(s) (DILs) can facilitate diagnosis and treatment by targeting biologically significant intra-prostatic foci. A PSMA ligand, [¹⁸F]DCFPyL (2-(3-{1-carboxy-5-[(6-[¹⁸F]fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentanedioic acid), is better than choline-based [¹⁸F]FCH (fluorocholine) in detecting and localizing DIL because of higher tumour contrast, particularly when imaging is delayed to 1 h post-injection. The goal of this study was to investigate whether the different imaging performance of [¹⁸F]FCH and [¹⁸F]DCFPyL can be explained by their kinetic behaviour in prostate cancer (PCa) and to evaluate whether DIL can be accurately detected and localized using a sh

SUBMITTER: Yang DM 

PROVIDER: S-EPMC7782622 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature