Ontology highlight
ABSTRACT:
SUBMITTER: Gray DA
PROVIDER: S-EPMC7782687 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nature communications 20210104 1
In Bacteroidetes, one of the dominant phyla of the mammalian gut, active uptake of large nutrients across the outer membrane is mediated by SusCD protein complexes via a "pedal bin" transport mechanism. However, many features of SusCD function in glycan uptake remain unclear, including ligand binding, the role of the SusD lid and the size limit for substrate transport. Here we characterise the β2,6 fructo-oligosaccharide (FOS) importing SusCD from Bacteroides thetaiotaomicron (Bt1762-Bt1763) to ...[more]