Tumour acidosis evaluated in vivo by MRI-CEST pH imaging reveals breast cancer metastatic potential.

ABSTRACT:

Background

Tumour acidosis is considered to play a central role in promoting cancer invasion and migration, but few studies have investigated in vivo how tumour pH correlates with cancer invasion. This study aims to determine in vivo whether tumour acidity is associated with cancer metastatic potential.

Methods

Breast cancer cell lines with different metastatic potentials have been characterised for several markers of aggressiveness and invasiveness. Murine tumour models have been developed and assessed for lung metastases and tumour acidosis has been assessed in vivo by a magnetic resonance imaging-based chemical exchange saturation transfer (CEST) pH imaging approach.

Results

The higher metastatic potential of 4T1 and TS/A primary tumours, in comparison to the less

SUBMITTER: Anemone A 

PROVIDER: S-EPMC7782702 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature