Differential transcript usage unravels gene expression alterations in Alzheimer's disease human brains.

ABSTRACT: Alzheimer's disease (AD) is the leading cause of dementia in aging individuals. Yet, the pathophysiological processes involved in AD onset and progression are still poorly understood. Among numerous strategies, a comprehensive overview of gene expression alterations in the diseased brain could contribute for a better understanding of the AD pathology. In this work, we probed the differential expression of genes in different brain regions of healthy and AD adult subjects using data from three large transcriptomic studies: Mayo Clinic, Mount Sinai Brain Bank (MSBB), and ROSMAP. Using a combination of differential expression of gene and isoform switch analyses, we provide a detailed landscape of gene expression alterations in the temporal and frontal lobes, harboring brain areas affected at e

SUBMITTER: Marques-Coelho D 

PROVIDER: S-EPMC7782705 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature