TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.

ABSTRACT: TARM1 is a member of the leukocyte immunoglobulin-like receptor family and stimulates macrophages and neutrophils in vitro by associating with FcRγ. However, the function of this molecule in the regulation of the immune system is unclear. Here, we show that Tarm1 expression is elevated in the joints of rheumatoid arthritis mouse models, and the development of collagen-induced arthritis (CIA) is suppressed in Tarm1^-/- mice. T cell priming against type 2 collagen is suppressed in Tarm1^-/- mice and antigen-presenting ability of GM-CSF-induced dendritic cells (GM-DCs) from Tarm1^-/- mouse bone marrow cells is impaired. We show that type 2 collagen is a functional ligand for TARM1 on GM-DCs and promotes DC maturation. Furthermore, soluble TARM1-Fc and TARM1-Flag

SUBMITTER: Yabe R 

PROVIDER: S-EPMC7782728 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature