Reciprocal interactions between tumour cell populations enhance growth and reduce radiation sensitivity in prostate cancer.

ABSTRACT: Intratumoural heterogeneity (ITH) contributes to local recurrence following radiotherapy in prostate cancer. Recent studies also show that ecological interactions between heterogeneous tumour cell populations can lead to resistance in chemotherapy. Here, we evaluated whether interactions between heterogenous populations could impact growth and response to radiotherapy in prostate cancer. Using mixed 3D cultures of parental and radioresistant populations from two prostate cancer cell lines and a predator-prey mathematical model to investigate various types of ecological interactions, we show that reciprocal interactions between heterogeneous populations enhance overall growth and reduce radiation sensitivity. The type of interaction influences the time of regrowth after radiation, and, at t

SUBMITTER: Paczkowski M 

PROVIDER: S-EPMC7782740 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature