EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures.

ABSTRACT:

Background

The epithelial-mesenchymal transition (EMT) enables dissociation of tumour cells from the primary tumour mass, invasion through the extracellular matrix, intravasation into blood vessels and colonisation of distant organs. Cells that revert to the epithelial state via the mesenchymal-epithelial transition cause metastases, the primary cause of death in cancer patients. EMT also empowers cancer cells with stem-cell properties and induces resistance to chemotherapeutic drugs. Understanding the driving factors of EMT is critical for the development of effective therapeutic interventions.

Methods

This manuscript describes the generation of a database containing EMT gene signatures derived from cell lines, patient-derived xenografts and patient studies across cancer ty

SUBMITTER: Vasaikar SV 

PROVIDER: S-EPMC7782839 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature