ARID1A upregulation predicts better survival in patients with urothelial bladder carcinoma.

ABSTRACT:

Objective

AT-rich interactive domain-containing protein 1A (ARID1A) is frequently mutated or deficient in various types of tumors. However, the role of ARID1A in bladder cancer remains unclear. We aimed to evaluate ARID1A expression and its biological role and correlation with prognosis in patients with urothelial bladder carcinoma (BUC).

Methods

ARID1A expression levels in BUC and normal tissues were assessed by immunohistochemistry and correlated with clinicopathological characteristics and patient outcomes. Downregulation of ARID1A was mimicked by transfection with small interfering RNA in T24 bladder cancer cells, and the effects on cell proliferation and migration were evaluated.

Results

ARID1A expression was significantly reduced in BUC tissues and was significa

SUBMITTER: Cao Q 

PROVIDER: S-EPMC7783253 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature