Parkinson's Disease in Teneurin Transmembrane Protein 4 (TENM4) Mutation Carriers.

ABSTRACT:

Introduction

Mutations in the teneurin transmembrane protein 4 (TENM4) gene, known to be involved in neuropsychiatric disorders, have been identified in three pedigree of essential tremor (ET) from Spain. ET has overlapping clinical manifestations and epidemiological symptoms with Parkinson's disease (PD), suggesting these two disorders may reflect common genetic risk factors. In this study, we investigated clinical and genetic manifestations in four unrelated pedigrees with both ET and PD in which TENM4 variants were identified.

Methods

We subsequently explored whether TENM4 variants contributed to the risk of developing PD. The frequency of TENM4 variants was evaluated from four PD pedigrees and other 407 subjects.

Results

The results rev

SUBMITTER: Pu JL 

PROVIDER: S-EPMC7783409 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature