The Roles of Stroma-Derived Chemokine in Different Stages of Cancer Metastases.

ABSTRACT: The intricate interplay between malignant cells and host cellular and non-cellular components play crucial role in different stages of tumor development, progression, and metastases. Tumor and stromal cells communicate to each other through receptors such as integrins and secretion of signaling molecules like growth factors, cytokines, chemokines and inflammatory mediators. Chemokines mediated signaling pathways have emerged as major mechanisms underlying multifaceted roles played by host cells during tumor progression. In response to tumor stimuli, host cells-derived chemokines further activates signaling cascades that support the ability of tumor cells to invade surrounding basement membrane and extra-cellular matrix. The host-derived chemokines act on endothelial cells to increase their

SUBMITTER: Hussain S 

PROVIDER: S-EPMC7783453 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature