Increased Lifetime Risk of ESRD in Familial IgA Nephropathy.

ABSTRACT:

Introduction

Familial IgA nephropathy (IgAN) has been widely reported. However, its clinicohistologic characteristics and long-term prognosis are not clear.

Methods

A total of 348 familial IgAN cases from 167 independent families were recruited and their clinicohistologic characteristics as well as lifetime risk of end-stage renal disease (ESRD) were compared to 1116 sporadic IgAN patients from the same geographic region.

Results

Of all familial IgAN patients, 60 (17%) came from 32 single-generation (SG; all affected individuals are siblings) families, whereas 286 (82%) came from 134 multiple-generation (MG; affected individuals were present in at least 2 consecutive generations) families. The lifetime ESRD risk was significantly higher in familial patients than spora

SUBMITTER: Shi M 

PROVIDER: S-EPMC7783566 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature