Pretreatment Brain Connectome Fingerprint Predicts Treatment Response in Major Depressive Disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) treatment is characterized by low remission rate and often involves weeks to months of treatment. Identification of pretreatment biomarkers of response may play a critical role in novel drug development, in enhanced prognostic predictions, and perhaps in providing more personalized medicine. Using a network restricted strength predictive modeling (NRS-PM) approach, the goal of the current study was to identify pretreatment functional connectome fingerprints (CFPs) that (1) predict symptom improvement regardless of treatment modality and (2) predict treatment specific improvement.

Methods

Functional magnetic resonance imaging and behavioral data from unmedicated patients with MDD (n = 200) were investigated. Participants were randomi

SUBMITTER: Fan S 

PROVIDER: S-EPMC7783890 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature