Omega-3 fatty acid supplementation is associated with favorable outcomes in patients with sepsis: an updated meta-analysis.

ABSTRACT:

Objectives

The efficacy of omega-3 fatty acids in the treatment of sepsis is controversial. We conducted an updated meta-analysis to clarify the efficacy of omega-3 fatty acids in patients with sepsis.

Methods

PubMed, EMBASE, and the Cochrane Library were searched for randomized clinical trials (RCTs) on omega-3 fatty acid supplementation in adults with sepsis.

Results

Twenty eligible RCTs involving 1514 patients were included in the meta-analysis. Omega-3 fatty acid supplementation was linked to reductions of mortality (I² = 0, relative risk [RR] = 0.82, 95% confidence interval [CI] = 0.69-0.97), the duration of mechanical ventilation (DMV; I² = 74%, weighted mean difference [WMD] = -2.20, 95% CI = -4.00 to -0.40), and intensive ca

SUBMITTER: Wang C 

PROVIDER: S-EPMC7783898 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature