A publicly available repository of ROH islands reveals signatures of selection in different livestock and pet species.

ABSTRACT:

Background

Runs of homozygosity (ROH) have become the state-of-the-art method for analysis of inbreeding in animal populations. Moreover, ROH are suited to detect signatures of selection via ROH islands and are used in other applications, such as genomic prediction and genome-wide association studies (GWAS). Currently, a vast amount of single nucleotide polymorphism (SNP) data is available online, but most of these data have never been used for ROH analysis. Therefore, we performed a ROH analysis on large medium-density SNP datasets in eight animal species (cat, cattle, dog, goat, horse, pig, sheep and water buffalo; 442 different populations) and make these results publicly available.

Results

The results include an overview of ROH islands per population and a comparison of

SUBMITTER: Gorssen W 

PROVIDER: S-EPMC7784028 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature