Ontology highlight
ABSTRACT:
SUBMITTER: Choi DI
PROVIDER: S-EPMC7784033 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Molecular brain 20210105 1
CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing chromatin structure. A reduction of CTCF expression is known to develop distinct clinical features. Furthermore, conditional knock out (cKO) study revealed reactive gliosis of astrocytes and microglia followed by age-dependent cell death in the excitatory neurons of CTCF cKO mice. To assess the cognitive ability in CTCF cKO mice of over 20 weeks of age, we examined pairwise discrimination (PD), PD reversal learn ...[more]