Six 1-halobenzoyl-4-(2-meth-oxy-phen-yl)piperazines having Z' values of one, two or four; disorder, pseudosymmetry, twinning and supra-molecular assembly in one, two or three dimensions.

ABSTRACT: Six 1-halobenzoyl-4-(2-meth-oxy-phen-yl)piperazines have been prepared using carbodi-imide-mediated coupling reactions between halo-benzoic acids and N-(2-meth-oxy-phen-yl)piperazine. The mol-ecules of 1-(4-fluoro-benzo-yl)-4-(2-meth-oxy-phen-yl)piperazine, C₁₈H₁₉FN₂O₂ (I), are linked into a chain of rings by a combination of C-H⋯O and C-H⋯π(arene) hydrogen bonds. 1-(4-Chloro-benzo-yl)-4-(2-meth-oxy-phen-yl)piperazine, C₁₈H₁₉ClN₂O₂ (II), crystallizes in the space group Pca2₁ with Z' = 4 and it exhibits both pseudosymmetry and inversion twinning: a combination of six C-H⋯O and two C-H⋯π(arene) hydrogen bonds generate a three-dimensional assembly. In 1-(4-bromo-benzo-yl)-4-

SUBMITTER: Harish Chinthal C 

PROVIDER: S-EPMC7784055 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature