History of lower-limb complications and risk of cancer death in people with type 2 diabetes.

ABSTRACT:

Background

Individuals with diabetes and lower-limb complications are at high risk for cardiovascular and all-cause mortality, but uncertainties remain in terms of cancer-related death in this population. We investigated this relationship in a large cohort of people with type 2 diabetes.

Methods

We used data from the Action in Diabetes and Vascular Disease: PreterAx and DiamicroN Modified-Release Controlled Evaluation (ADVANCE) study. The primary outcome was adjudicated cancer death; secondary outcomes were overall and site-specific incident cancers, determined according to the International Classification of Diseases Code (ICD-10). We compared outcomes in individuals with (versus without) a baseline history of lower-limb complications (peripheral artery disease (PAD) or sen

SUBMITTER: Mohammedi K 

PROVIDER: S-EPMC7784290 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature