A novel high-content screening approach for the elucidation of C. jejuni biofilm composition and integrity.

ABSTRACT:

Background

Campylobacter jejuni is the leading cause of bacterial gastroenteritis worldwide and the main source of infection is contaminated chicken meat. Although this important human pathogen is an obligate microaerophile, it must survive atmospheric oxygen conditions to allow transmission from contaminated chicken meat to humans. It is becoming increasingly evident that formation of biofilm plays a key role in the survival of this organism for extended periods on poultry products. We have recently demonstrated a novel inducible model for the study of adherent C. jejuni biofilm formation under aerobic conditions. By taking advantage of supercoiling mediated gene regulation, incubation of C. jejuni with subinhibitory concentrations of the Gyrase B inhibitor novobiocin was shown to

SUBMITTER: Whelan MVX 

PROVIDER: S-EPMC7784365 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature