A bidirectional Mendelian randomization study supports causal effects of kidney function on blood pressure.

ABSTRACT: Blood pressure and kidney function have a bidirectional relation. Hypertension has long been considered as a risk factor for kidney function decline. However, whether intensive blood pressure control could promote kidney health has been uncertain. The kidney is known to have a major role in affecting blood pressure through sodium extraction and regulating electrolyte balance. This bidirectional relation makes causal inference between these two traits difficult. Therefore, to examine the causal relations between these two traits, we performed two-sample Mendelian randomization analyses using summary statistics of large-scale genome-wide association studies. We selected genetic instruments more likely to be specific for kidney function using meta-analyses of complementary kidney function bio

SUBMITTER: Yu Z 

PROVIDER: S-EPMC7784392 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature