Immunology, immunopathogenesis and immunotherapeutics of COVID-19; an overview.

ABSTRACT: Coronavirus disease 2019 (COVID-19) infection which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a "public health emergency of international concern" (PHEIC). The infection is highly contagious, has a high mortality rate, and its pathophysiology remains poorly understood. Pulmonary inflammation with substantial lung damage together with generalized immune dysregulation are major components of COVID-19 pathogenesis. The former component, lung damage, seems to be at least in part a consequence of immune dysregulation. Indeed, studies have revealed that immune alteration is not merely an association, as it might occur in systemic infections, but, very likely, the core pathogenic element of COVID-19. In addition, precise management of immune response in

SUBMITTER: Mohamed Khosroshahi L 

PROVIDER: S-EPMC7784533 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature