Diminished Learning Over Repeated Exposures (LORE) in preclinical Alzheimer's disease.

ABSTRACT:

Introduction

We determine whether diminished Learning Over Repeated Exposures (LORE) identifies subtle memory decrements in cognitively unimpaired (CU) older adults with Alzheimer's disease (AD) biomarker burden.

Methods

Ninety-four CU participants (mean age = 77.6 ± 5.02) completed a challenging associative memory test, at home, monthly, for up to 1 year (mean = 9.97 months) on a study-issued iPad. Learning curves for face-name memory were computed for two versions completed monthly: same face-name pairs (A-A-A) and alternate face-name pairs (B-C-D). Positron emission tomography (PET) imaging characterized global amyloid (Pittsburgh Compound-B (PiB); amyloid beta (Aβ)+/-) and regional tau burden (flortaucipir).

Results

Diminished LORE for same (but not alternate) fac

SUBMITTER: Samaroo A 

PROVIDER: S-EPMC7784542 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature