Crystal structures of 2-amino-2-oxoethyl 4-bromo-benzoate, 2-amino-2-oxoethyl 4-nitro-benzoate and 2-amino-2-oxoethyl 4-amino-benzoate monohydrate.

ABSTRACT: The title mol-ecules were synthesized by the reaction of 4-substituted sodium benzoates with chloro-acetic acid amide in the presence of di-methyl-formamide. The yields of 2-amino-2-oxoethyl 4-bromo-benzoate, C₉H₈BrNO₃, I, 2-amino-2-oxoethyl 4-nitro-benzoate, C₉H₈N₂O₅, II, and 2-amino-2-oxoethyl 4-amino-benzoate monohydrate, C₉H₁₀N₂O₃·H₂O, III, are 86, 78 and 88%, respectively. The low yield of II is explained by the reduced reactivity of the mol-ecule in a nucleophilic exchange reaction because of the negative induction and negative mesomeric effects of the nitro group on the benzene ring. Single crystals were obtained from the pro

SUBMITTER: Sapayev FA 

PROVIDER: S-EPMC7784646 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature