Synthesis and structure of a 1:1 co-crystal of hexa-methyl-ene-tetra-mine carb-oxy-borane and acetamino-phen.

ABSTRACT: Hexa-methyl-ene-tetra-mine carboacetamino-phenborane, a mol-ecule with two pharmacophores attached to a central carb-oxy-borate moiety, was synthesized and crystals were grown with an acetamino-phen co-crystal former to result in the title 1:1 co-crystal [hexa-methyl-ene-tetra-mine 4-acetamido-phenyl 2-boranyl-acetate-4-acet-amido-phenol (1/1)], C₁₅H₂₂BN₅O₃·C₈H₉NO₂. In the first of these mol-ecules, both the borate-ester and acetyl-amino groups are considerably twisted away from the plane of the inter-vening benzene ring [dihedral angles = 76.89 (9) and 65.42 (9)°, respectively]. The extended structure of this co-crystal features N-H⋯O and O-H⋯O hydrogen bonds, which link the components into (100) sheets and weak

SUBMITTER: Ayudhya T 

PROVIDER: S-EPMC7784649 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature