Modular prophage interactions driven by capsule serotype select for capsule loss under phage predation.

ABSTRACT: Klebsiella species are able to colonize a wide range of environments and include worrisome nosocomial pathogens. Here, we sought to determine the abundance and infectivity of prophages of Klebsiella to understand how the interactions between induced prophages and bacteria affect population dynamics and evolution. We identified many prophages in the species, placing these taxa among the top 5% of the most polylysogenic bacteria. We selected 35 representative strains of the Klebsiella pneumoniae species complex to establish a network of induced phage-bacteria interactions. This revealed that many prophages are able to enter the lytic cycle, and subsequently kill or lysogenize closely related Klebsiella strains. Although 60% of the tested strains could produce phages that infect at least one

SUBMITTER: de Sousa JAM 

PROVIDER: S-EPMC7784688 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature