Phase I/II randomized study of proton beam with anti-VEGF for exudative age-related macular degeneration: long-term results.

ABSTRACT:

Background/objective

To determine if treatment of exudative age-related macular degeneration (eAMD) using proton beam therapy (PBT) combined with intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is safe and effective long term.

Subject/methods

Thirty eyes with newly diagnosed eAMD were enrolled in a phase I/II prospective, sham-controlled double-masked university study. Eyes were randomized 1:1:1-24 GyE, 16 GyE or sham radiation, and treated with three initial monthly intravitreal ranibizumab or bevacizumab. Subsequent anti-VEGF reinjection was based on monthly optical coherence tomography and examination for 2 years and standard of care thereafter.

Results

A total of 23 eyes completed 2-year study follow-up, of which 16 maintained monthly foll

SUBMITTER: Mukkamala LK 

PROVIDER: S-EPMC7784696 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature