Effect of interictal epileptiform discharges on EEG-based functional connectivity networks.

ABSTRACT:

Objective

Functional connectivity networks (FCNs) based on interictal electroencephalography (EEG) can identify pathological brain networks associated with epilepsy. FCNs are altered by interictal epileptiform discharges (IEDs), but it is unknown whether this is due to the morphology of the IED or the underlying pathological activity. Therefore, we characterized the impact of IEDs on the FCN through simulations and EEG analysis.

Methods

We introduced simulated IEDs to sleep EEG recordings of eight healthy controls and analyzed the effect of IED amplitude and rate on the FCN. We then generated FCNs based on epochs with and without IEDs and compared them to the analogous FCNs from eight subjects with infantile spasms (IS), based on 1340 visually marked IEDs. Differences in net

SUBMITTER: Hu DK 

PROVIDER: S-EPMC7784722 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature