Study of the TEAD-binding domain of the YAP protein from animal species.

ABSTRACT: The Hippo signaling pathway, which plays a central role in the control of organ size in animals, is well conserved in metazoans. The most downstream elements of this pathway are the TEAD transcription factors that are regulated by their association with the transcriptional coactivator YAP. Therefore, the creation of the binding interface that ensures the formation of the YAP:TEAD complex is a critical molecular recognition event essential for the development/survival of many living organisms. In this report, using the available structural information on the YAP:TEAD complex, we study the TEAD-binding domain of YAP from different animal species. This analysis of more than 400 amino acid sequences reveals that the residues from YAP involved in the formation of the two main contact regions wi

SUBMITTER: Mesrouze Y 

PROVIDER: S-EPMC7784741 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature