Structural motifs in protein cores and at protein-protein interfaces are different.

ABSTRACT: Structures of proteins and protein-protein complexes are determined by the same physical principles and thus share a number of similarities. At the same time, there could be differences because in order to function, proteins interact with other molecules, undergo conformations changes, and so forth, which might impose different restraints on the tertiary versus quaternary structures. This study focuses on structural properties of protein-protein interfaces in comparison with the protein core, based on the wealth of currently available structural data and new structure-based approaches. The results showed that physicochemical characteristics, such as amino acid composition, residue-residue contact preferences, and hydrophilicity/hydrophobicity distributions, are similar in protein core and

SUBMITTER: Hadarovich A 

PROVIDER: S-EPMC7784743 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature