JAK-STAT Pathway Inhibition and their Implications in COVID-19 Therapy.

ABSTRACT: As the incidence of COVID-19 increases with time, more and more efforts are made to pave a way out for the therapeutic strategies to deal with the disease progression. Inflammation being a significant influencer in COVID-19 patients, it drives our focus onto the signaling cascades of the JAK/STAT pathway. JAK phosphorylation mediated by cytokine receptor activation leads to phosphorylation of STATs that translocate into the nucleus to translate for inflammatory mediators. The SARS-CoV-2 structural proteins like spike, nucleocapsid, membrane and envelope proteins along with the non- structural proteins 1-16 including proteases like 3CL ^pro and PL^pro promote its entry and survival in hosts. The SARS-CoV-2 infection triggers inflammation via the JAK/STAT pathway leading

SUBMITTER: Satarker S 

PROVIDER: S-EPMC7784782 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature