Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patients.

ABSTRACT:

Background

COVID-19 counts 46 million people infected and killed more than 1.2 million. Hypoxaemia is one of the main clinical manifestations, especially in severe cases. HIF1α is a master transcription factor involved in the cellular response to oxygen levels. The immunopathogenesis of this severe form of COVID-19 is poorly understood.

Methods

We performed scRNAseq from leukocytes from five critically ill COVID-19 patients and characterized the expression of hypoxia-inducible factor1α and its transcriptionally regulated genes. Also performed metanalysis from the publicly available RNAseq data from COVID-19 bronchoalveolar cells.

Results

Critically-ill COVID-19 patients show a shift towards an immature myeloid profile in peripheral blood cells, including band neutroph

SUBMITTER: Taniguchi-Ponciano K 

PROVIDER: S-EPMC7784832 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature