Design and in silico study of the novel coumarin derivatives against SARS-CoV-2 main enzymes.

ABSTRACT: The novel coronavirus (SARS-CoV-2) causes severe acute respiratory syndrome and can be fatal. In particular, antiviral drugs that are currently available to treat infection in the respiratory tract have been experienced, but there is a need for new antiviral drugs that are targeted and inhibit coronavirus. The antiviral properties of organic compounds found in nature, especially coumarins, are known and widely studied. Coumarins, which are also metabolites in many medicinal drugs, should be investigated as inhibitors against coronavirus due to their pharmacophore properties (low toxicity and high pharmacokinetic properties). The easy addition of substituents to the chemical structures of coumarins makes these structures unique for the drug design. This study focuses on factors that increas

SUBMITTER: Ozdemir M 

PROVIDER: S-EPMC7784838 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature