Role of the medial prefrontal cortex in the effects of rapid acting antidepressants on decision-making biases in rodents.

ABSTRACT: Major depressive disorder is a significant and costly cause of global disability. Until the discovery of the rapid acting antidepressant (RAAD) effects of ketamine, treatments were limited to drugs that have delayed clinical benefits. The mechanism of action of ketamine is currently unclear but one hypothesis is that it may involve neuropsychological effects mediated through modulation of affective biases (where cognitive processes such as learning and memory and decision-making are modified by emotional state). Previous work has shown that affective biases in a rodent decision-making task are differentially altered by ketamine, compared to conventional, delayed onset antidepressants. This study sought to further investigate these effects by comparing ketamine with other NMDA antagonists u

SUBMITTER: Hales CA 

PROVIDER: S-EPMC7784869 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature