Blood-Brain Barrier Leakage Is Increased in Parkinson's Disease.

ABSTRACT:

Background

Blood-brain barrier (BBB) disruption has been noted in animal models of Parkinson's disease (PD) and forms the basis of the vascular hypothesis of neurodegeneration, yet clinical studies are lacking.

Objective

To determine alterations in BBB integrity in PD, with comparison to cerebrovascular disease.

Methods

Dynamic contrast enhanced magnetic resonance images were collected from 49 PD patients, 15 control subjects with cerebrovascular disease [control positive (CP)] and 31 healthy control subjects [control negative (CN)], with all groups matched for age. Quantitative maps of the contrast agent transfer coefficient across the BBB (K ^trans) and plasma volume (v _p ) were produced using Patlak analysis. Differences in K</

SUBMITTER: Al-Bachari S 

PROVIDER: S-EPMC7784911 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature