Modulation of arousal and sleep/wake architecture by M₁ PAM VU0453595 across young and aged rodents and nonhuman primates.

ABSTRACT: Degeneration of basal forebrain cholinergic circuitry represents an early event in the development of Alzheimer's disease (AD). These alterations in central cholinergic function are associated with disruptions in arousal, sleep/wake architecture, and cognition. Changes in sleep/wake architecture are also present in normal aging and may represent a significant risk factor for AD. M₁ muscarinic acetylcholine receptor (mAChR) positive allosteric modulators (PAMs) have been reported to enhance cognition across preclinical species and may also provide beneficial effects for age- and/or neurodegenerative disease-related changes in arousal and sleep. In the present study, electroencephalography was conducted in young animals (mice, rats and nonhuman primates [NHPs]) and in aged mice to

SUBMITTER: Gould RW 

PROVIDER: S-EPMC7784923 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature