Association between visual acuity, lesion activity markers and retreatment decisions in neovascular age-related macular degeneration.

ABSTRACT:

Background/objectives

To investigate the association between optical coherence tomography (OCT) markers of lesion activity and changes in visual acuity (VA) during anti-vascular endothelial growth factor (anti-VEGF) therapy of eyes diagnosed with neovascular age-related macular degeneration (nAMD); and how VA and OCT markers are considered in physicians' decision to retreat with anti-VEGFs.

Subjects/methods

Retrospective, non-comparative, non-randomised cohort study involving electronic medical record data collected from 1190 patient eyes with nAMD diagnosis at two sites in the United Kingdom. Two sub-cohorts consisting of 321 and 301 eyes, respectively, were selected for analyses.

Results

In 321 eyes, absence of IRF or SRF at ≥2 clinic visits resulted in a gain of fi

SUBMITTER: Chakravarthy U 

PROVIDER: S-EPMC7784949 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature