Vascular actions of peripheral CGRP in migraine-like photophobia in mice.

ABSTRACT:

Background

Calcitonin gene-related peptide is recognized as a key player in migraine, yet the mechanisms and sites of calcitonin gene-related peptide action remain unknown. The efficacy of calcitonin gene-related peptide-blocking antibodies as preventative migraine drugs supports a peripheral site of action, such as the trigeminovasculature. Given the apparent disconnect between the importance of vasodilatory peptides in migraine and the prevailing opinion that vasodilation is an epiphenomenon, the goal of this study was to test whether vasodilation plays a role in calcitonin gene-related peptide-induced light aversive behavior in mice.

Methods

Systemic mean arterial pressure and light aversive behavior were measured after intraperitoneal administration of calcitonin gene-re

SUBMITTER: Mason BN 

PROVIDER: S-EPMC7785273 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature