Designing Evolutionary-based Interception Strategies to Block the Transition from Precursor Phases to Multiple Myeloma.

ABSTRACT: The development of next-generation sequencing technology has dramatically improved our understanding of the genetic landscape of multiple myeloma. Several new drivers and recurrent events have been reported and linked to a potential driver role. This complex landscape is enhanced by intraclonal mutational heterogeneity and variability introduced through the dimensions of time and space. The evolutionary history of multiple myeloma is driven by both the accumulation of different genomic drivers and by the activity of different mutational processes active overtime. In this review, we describe how these new findings and sequencing technologies have been progressively allowed to understand and reshape our knowledge of the complexity of multiple myeloma at each of its developmental stages: prem

SUBMITTER: Maura F 

PROVIDER: S-EPMC7785564 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature