Cu/Zn Superoxide Dismutase (Sod1) regulates the canonical Wnt signaling pathway.

ABSTRACT: Cu/Zn Superoxide Dismutase (Sod1) catalyzes the disproportionation of cytotoxic superoxide radicals (O₂^•-) into oxygen (O₂) and hydrogen peroxide (H₂O₂), a key signaling molecule. In Saccharomyces cerevisiae, we previously discovered that Sod1 participates in an H₂O₂-mediated redox signaling circuit that links nutrient availability to the control of energy metabolism. In response to glucose and O₂, Sod1-derived H₂O₂ stabilizes a pair of conserved plasma membrane kinases - yeast casein kinase 1 and 2 (Yck1/2) - that signal glycolytic growth and the repression of respiration. The Yck1/2 homolog in humans, casein kinase 1-γ (CK1γ), is an integral component of the Wingless and Int-1 (W

SUBMITTER: Chandrasekharan B 

PROVIDER: S-EPMC7785591 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature