Progesterone Receptor Is a Haploinsufficient Tumor-Suppressor Gene in Cervical Cancer.

ABSTRACT: Tumor-suppressor genes (TSG) are often deleted or transcriptionally suppressed in cancer. PGR codes for progesterone receptor (PR), a transcription factor whose function depends on its ligand. Although PR expression is often undetectable in cervical cancer, its relevance to the endocrine-related etiology of this prevalent gynecological disease remains unclear. In this study, we show that the deletion of one Pgr allele in cervical epithelium promoted spontaneous cervical cancer in human papilloma viral oncogene-expressing transgenic mice as efficiently as the ablation of both Pgr alleles. We also show that tumors arising in the transgenic mice with one or both Pgr alleles did not express PR or expressed at the reduced levels compared with the normal epithelium. P

SUBMITTER: Park Y 

PROVIDER: S-EPMC7785602 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature