Combining therapeutic vaccines with chemo- and immunotherapies in the treatment of cancer.

ABSTRACT:

Introduction

Breakthroughs in cancer immunotherapy have spurred interest in the development of vaccines to mediate prophylactic protection and therapeutic efficacy against primary tumors or to prevent relapse. However, immunosuppressive mechanisms employed by cancer cells to generate effective resistance have hampered clinical translation of therapeutic cancer vaccines. To enhance vaccine efficacy, the immunomodulatory properties of cytoreductive therapies could amplify a cancer-specific immune response.

Areas covered

Herein, the authors discuss therapeutic cancer vaccines that harness whole cells and antigen-targeted vaccines. First, recent advancements in both autologous and allogeneic whole-cell vaccines and combinations with checkpoint blockade and chemotherapy are revie

SUBMITTER: Kerr MD 

PROVIDER: S-EPMC7785654 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature