ImmunoPET Imaging of Pancreatic Tumors with ⁸⁹Zr-Labeled Gold Nanoparticle-Antibody Conjugates.

ABSTRACT:

Purpose

Targeted delivery in vivo remains an immense roadblock for the translation of nanomaterials into the clinic. The greatest obstacle is the mononuclear phagocyte system (MPS), which sequesters foreign substances from general circulation and causes accumulation in organs such as the liver and spleen. The purpose of this study was to determine whether attaching an active targeting antibody, 5B1, to the surface of gold nanoparticles and using clodronate liposomes to deplete liver and splenic macrophages could help to minimize uptake by MPS organs, increase targeted delivery to CA19.9-positive pancreatic tumors, and enhance pancreatic tumor delineation.

Procedures

To produce the antibody-gold nanoparticle conjugate (Ab-AuNP), the Ab was conjugated to p-isothiocyanatobenzyl

SUBMITTER: Sobol NB 

PROVIDER: S-EPMC7785666 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature