Detection of Chemotherapy-resistant Pancreatic Cancer Using a Glycan Biomarker, sTRA.

ABSTRACT:

Purpose

A subset of pancreatic ductal adenocarcinomas (PDACs) is highly resistant to systemic chemotherapy, but no markers are available in clinical settings to identify this subset. We hypothesized that a glycan biomarker for PDACs called sialylated tumor-related antigen (sTRA) could be used for this purpose.

Experimental design

We tested for differences between PDACs classified by glycan expression in multiple systems: sets of cell lines, organoids, and isogenic cell lines; primary tumors; and blood plasma from human subjects.

Results

The sTRA-expressing models tended to have stem-like gene expression and the capacity for mesenchymal differentiation, in contrast to the nonexpressing models. The sTRA cell lines also had significantly increased resistance to seven dif

SUBMITTER: Gao C 

PROVIDER: S-EPMC7785673 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature