International Consensus Definition of DNA Methylation Subgroups in Juvenile Myelomonocytic Leukemia.

ABSTRACT:

Purpose

Known clinical and genetic markers have limitations in predicting disease course and outcome in juvenile myelomonocytic leukemia (JMML). DNA methylation patterns in JMML have correlated with outcome across multiple studies, suggesting it as a biomarker to improve patient stratification. However, standardized approaches to classify JMML on the basis of DNA methylation patterns are lacking. We, therefore, sought to define an international consensus for DNA methylation subgroups in JMML and develop classification methods for clinical implementation.

Experimental design

Published DNA methylation data from 255 patients with JMML were used to develop and internally validate a classifier model. Accuracy across platforms (EPIC-arrays and MethylSeq) was tested using a technic

SUBMITTER: Schonung M 

PROVIDER: S-EPMC7785676 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature