Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role.

ABSTRACT: Mitochondria are recognized as the main source of ATP to meet the energy demands of the cell. ATP production occurs by oxidative phosphorylation when electrons are transported through the electron transport chain (ETC) complexes and develop the proton motive force across the inner mitochondrial membrane that is used for ATP synthesis. Studies since the 1960s have been concentrated on the two models of structural organization of ETC complexes known as "solid-state" and "fluid-state" models. However, advanced new techniques such as blue-native gel electrophoresis, mass spectroscopy, and cryogenic electron microscopy for analysis of macromolecular protein complexes provided new data in favor of the solid-state model. According to this model, individual ETC complexes are assembled into macromo

SUBMITTER: Javadov S 

PROVIDER: S-EPMC7785696 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature