Prognostic significance of lymph node ratio after neoadjuvant chemoradiation therapy for esophageal squamous cell carcinoma.

ABSTRACT:

Purpose

We retrospectively evaluated the prognostic significance of lymph node ratio (LNR) in patients with esophageal squamous cell carcinoma who underwent neoadjuvant concurrent chemoradiation therapy (NCRT) followed by surgery.

Materials and methods

In total, 270 patients who underwent NCRT followed by surgery between August 2005 and December 2015 were included. They were divided into three groups: LNR 0 (n = 196), LNR low (0 < LNR ≤ 0.1; n = 63), and LNR high (>0.1; n = 11). The primary endpoint was overall survival (OS), and the secondary endpoints were freedom from local recurrence (FFLR), distant metastasis-free survival (DMFS), and disease-free survival (DFS).

Results

The median number of retrieved lymph nodes per patient was 33. Pathologically, 74 patients ha

SUBMITTER: Jang JY 

PROVIDER: S-EPMC7785840 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature