Characterizing the impact of adversity, abuse, and neglect on adolescent amygdala resting-state functional connectivity.

ABSTRACT: Characterizing typologies of childhood adversity may inform the development of risk profiles and corresponding interventions aimed at mitigating its lifelong consequences. A neurobiological grounding of these typologies requires systematic comparisons of neural structure and function among individuals with different exposure histories. Using seed-to-whole brain analyses, this study examined associations between childhood adversity and amygdala resting-state functional connectivity (rs-fc) in adolescents aged 11-19 years across three independent studies (N = 223; 127 adversity group) in both general and dimensional models of adversity (comparing abuse and neglect). In a general model, adversity was associated with altered amygdala rs-fc with clusters within the left anterior lateral prefron

SUBMITTER: Cheng TW 

PROVIDER: S-EPMC7786040 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature