Heritable Gut Microbiome Associated with Salmonella enterica Serovar Pullorum Infection in Chickens.

ABSTRACT: Pullorum disease is one of the most common diarrhea-related diseases caused by Salmonella enterica subspecies enterica serovar Gallinarum biovar Pullorum (S Pullorum); it negatively affects the poultry industry. However, limited studies have explored the association between the gut microbiota and S Pullorum infection in chickens. In the present study, we performed a microbiome comparison and a microbiome genome-wide association study (mGWAS) to investigate the association among the host genetics, the gut microbiota, and pullorum disease in chickens. We found that S Pullorum infection in chickens could alter the abundance of 39 bacterial genera (P < 0.05). The altered structure and composition of the gut microbiota were also detected in the offsprin

SUBMITTER: Ding J 

PROVIDER: S-EPMC7786134 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature